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KMID : 0606920100180020219
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Biomolecules & Therapeutics
2010 Volume.18 No. 2 p.219 ~ p.225
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Anti-Stress Effects of Ginsenoside Rg3-Standardized Ginseng Extract in Restraint Stressed Animals
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Kim Chung-Soo
Oh Ki-Wan
Cheong Jae-Hoon
Hong Geun-Pyo
Park Se-Ho
Jo Young-Jun
Kim Hae-Jung
Han Jin-Yi
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Abstract
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We tested whether ginsenosides Rg3-standardized ginseng extract (RGE) has anti-stress effects in restraint-stressed animals. RGE increased time spent in the open arms and open arm entries in the elevated plus-maze test. In addition, RGE blocked the reduction of center zone distance and stereotypes behaviors in the open-field test. RGE also increased head dips in stressed mice, indicating anxiolytic-like effects. Stress decreased movement distance and duration, burrowing, and rearing frequency but increased face washing and grooming. RGE significantly reversed burrowing and rearing activity in stressed mice. In addition, we measured sleep architecture in restraint stressed rats using EEG recorder. Stress increased rapid eye movement (REM) sleep, but total sleep and non-rapid eye movement (NREM) sleep were not changed. RGE did not affect sleep architecture in stressed rats. These behavioral experiments suggest that RGE has anti-stress effects in restraint-stressed animal models.
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KEYWORD
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Anti-stress, Ginsenoside Rg3-standardized ginseng extract (RGE), Restraint stress, Behaviors, Electroencephalogram (EEG), Sleep
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